Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on the vasculogenesis in rat cerebral cortex.

M Mato1, S Ookawara, T Namiki

  • 1Department of Anatomy, Jichi Medical School, Tochigi, Japan.

The Anatomical Record
|July 1, 1989
PubMed
Summary

This study details cerebral cortex vasculogenesis in developing rats, revealing how vascular cords fuse. It highlights the role of tip cells and intercellular spaces in forming new blood vessels for brain development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Propylthiouracil-induced vasculitis presenting as purpuric plaques on cheeks.

Clinical and experimental dermatology·2021
Same author

Stevens-Johnson syndrome induced by tonic water.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Image Gallery: Acquired anhidrosis associated with alcohol-related peripheral neuropathy, a potential cause of anhidrosis due to reduced innervation of eccrine glands.

The British journal of dermatology·2019
Same author

Borst-Jadassohn phenomenon arising from a seborrhoeic keratosis and its characteristic dermoscopic features.

Clinical and experimental dermatology·2018
Same author

A case of neutrophilic dermatoses including pyoderma gangrenosum as a continuous disease spectrum to SAPHO syndrome.

Clinical and experimental dermatology·2018
Same author

Chronic active Epstein-Barr virus infection with cutaneous lymphoproliferation: haemophagocytosis in the skin and haemophagocytic syndrome.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017

Area of Science:

  • Developmental biology
  • Neuroscience
  • Vascular biology

Background:

  • The cerebral cortex relies on a complex capillary network for blood supply.
  • Understanding the formation of these blood vessels (vasculogenesis) is crucial for brain development.

Purpose of the Study:

  • To investigate the process of vasculogenesis in the developing rat cerebral cortex.
  • To elucidate the cellular mechanisms involved in the formation and fusion of cerebral blood vessels.

Main Methods:

  • Light and electron microscopy were employed.
  • Intravenous administration of horseradish peroxidase (HRP) was used to trace vascular development.
  • Study focused on rat embryos between 11-18 days post-conception.

Main Results:

Related Experiment Videos

  • Vasculogenesis involves tip cells extending tentacles to connect vascular cords.
  • Horseradish peroxidase (HRP) demonstrated blood serum leakage into extravascular spaces during fusion.
  • Vascular cords fuse, forming primitive lumens that enlarge to accommodate blood cells.

Conclusions:

  • Cerebral vasculogenesis is a dynamic process involving vascular cord fusion mediated by tip cell interactions.
  • Endothelial cell degeneration plays a minor role in lumen formation.
  • The role of cerebral pericytal macrophages (CPM) in this process requires further investigation.