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Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension

Tolga Çimen1, Murat Bilgin1, Ahmet Akyel1

  • 1Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Korean Circulation Journal
|November 10, 2016
PubMed

Insights

Non-dipper hypertension is linked to higher endocan and hsCRP levels, suggesting these markers may help identify patients at higher risk for target organ damage. This study highlights endocan as a potential biomarker for hypertension management.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Hypertension Research

Background:

  • Non-dipper hypertension is associated with endothelial dysfunction.
  • Endocan is a potential novel marker for endothelial dysfunction.

Purpose of the Study:

  • To investigate the association between circadian blood pressure patterns and plasma endocan levels.
  • To examine the relationship between non-dipping hypertension, endocan, and high-sensitivity C-reactive protein (hsCRP).

Main Methods:

  • Ambulatory blood pressure monitoring was conducted on 35 non-dipper hypertensives, 35 dipper hypertensives, and 35 healthy controls.
  • Plasma endocan levels were measured using enzyme-linked immunosorbent assay.
  • Serum hsCRP levels were also quantified.

Main Results:

  • Non-dipper hypertensives exhibited significantly higher nocturnal blood pressure compared to dippers.
  • Plasma endocan and hsCRP levels were significantly elevated in non-dipper patients compared to dippers and controls.
  • Endocan and hsCRP were independently associated with the non-dipping blood pressure pattern.

Conclusions:

  • Elevated endocan levels are present in non-dipper hypertensive patients.
  • Endocan and hsCRP may serve as independent predictors of the non-dipping pattern in hypertension.
  • These findings suggest a potential role for endocan in identifying hypertensive patients at higher risk for target organ damage.
Abstract

Keywords:
Blood pressure monitoring, ambulatoryDipping patternEndocanHypertension

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