Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

862
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
862
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

79
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
79
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

6.5K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.5K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

2.2K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Species differences influencing the safety assessment of CD3 T-cell engagers.

Journal of immunotoxicology·2026
Same author

Variant classification for mucopolysaccharidosis type I; ACMG/AMP specification for IDUA from the ClinGen lysosomal diseases variant curation expert panel.

Molecular genetics and metabolism·2026
Same author

Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Corrigendum to "Role of integrated cancer nanomedicine in overcoming drug resistance" [Adv. Drug Deliv. Rev. 65 (2013) 1784-1802].

Advanced drug delivery reviews·2026
Same author

Delivery of ATSP-7041 by Minimally Invasive Nasal Depot (MIND) to Target Diffuse Intrinsic Pontine Glioma.

Molecular cancer therapeutics·2026
Same author

Formulation considerations in enhancing olfactory mucosal deposition for nose-to-brain drug delivery.

Drug delivery and translational research·2026

Related Experiment Video

Updated: Mar 12, 2026

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

9.8K

Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases.

Dipti Deshpande1, David R Janero1, Victor Segura-Ibarra2

  • 1Northeastern University, Boston, Massachusetts.

Methodist Debakey Cardiovascular Journal
|November 10, 2016
PubMed
Summary

This review explores how nucleic acids regulate endothelial function and nanotherapeutics for cardiovascular diseases. It highlights targets for treating endothelial dysfunction and vascular diseases.

Keywords:
CVDDNA damagecardiovascular diseasesendotheliuminflammationmiRNAnanoparticle deliverynucleic acidsoligonucleotide-based therapeuticsoxidative stress

More Related Videos

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells
09:58

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

8.1K
Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
10:33

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

11.3K

Related Experiment Videos

Last Updated: Mar 12, 2026

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

9.8K
Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells
09:58

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

8.1K
Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
10:33

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

11.3K

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Nanomedicine

Background:

  • Endothelial dysfunction is central to cardiovascular diseases, involving immune system components.
  • Understanding its mechanisms is crucial for developing effective vascular disease treatments.

Purpose of the Study:

  • To review nucleic acid-based regulation of endothelial function.
  • To discuss nanotherapeutic strategies targeting endothelial dysfunction in cardiovascular disorders.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of nucleic acid roles in endothelial health.
  • Examination of nanotherapeutic applications.

Main Results:

  • Nucleic acids play a key role in endothelial function.
  • Various nanotherapeutic platforms are being developed.
  • Targeting endothelial dysfunction offers therapeutic potential.

Conclusions:

  • Nucleic acid-based therapies show promise for cardiovascular diseases.
  • Nanotherapeutics can be tailored to address endothelial dysfunction.
  • Further research can advance vascular disease treatment.