Collagenopathies-Implications for Abdominal Wall Reconstruction: A Systematic Review

Area of Science:

• Biomedical Science
• Genetics
• Surgical Pathology

Background:

• Hernia formation etiology is debated, involving mechanical strain, surgery, and developmental factors.
• Ventral hernias often result from abdominal surgery but have multifactorial causes.
• Collagen vascular diseases, such as Ehlers-Danlos syndrome, are explored as contributing factors.

Purpose of the Study:

• To investigate the link between collagenopathies and ventral hernia formation.
• To review existing literature on the role of abnormal collagen in hernias.

Main Methods:

• A systematic review of Spanish and English literature was conducted.
• Searched PubMed and Cochrane databases using keywords: "collagenopathies," "Ehlers-Danlos," and "ventral hernia."
• Analyzed 61 relevant articles out of 352 initial search results.

Main Results:

• A preliminary search identified 352 articles.
• 61 articles were selected for the final review.
• No high-level clinical data definitively links collagenopathies and hernia formation.

Conclusions:

• Defects in collagen formation are suggested as a common factor in hernias.
• Pathologic studies indicate a trend linking abnormal collagen processing to hernia development.
• Further clinical data is required to establish a clear association between collagenopathies and hernias.