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Pulmonary sequestration associated with significant elevation of serum carbohydrate antigen 19-9: report of two cases
1Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Insights
Markedly elevated serum Carbohydrate antigen 19-9 (CA19-9) levels in two patients were linked to pulmonary sequestration. Surgical removal of the lung lesion normalized CA19-9 levels, suggesting sequestration as the cause.
Area of Science:
- Thoracic Surgery
- Medical Diagnostics
- Oncology
Background:
- Pulmonary sequestration is a rare congenital lung malformation.
- Elevated serum tumor markers can sometimes be associated with benign conditions.
Observation:
- Two young women presented with extremely elevated serum Carbohydrate antigen 19-9 (CA19-9).
- Imaging revealed lung lesions and anomalous arteries, leading to a diagnosis of pulmonary sequestration.
- Positron emission tomography/computed tomography (PET/CT) scans were used to rule out malignancy.
Findings:
- Lobectomy confirmed the diagnosis of pulmonary sequestration in both patients.
- Post-surgery, serum CA19-9 levels rapidly returned to normal.
Implications:
- This case series suggests that significantly elevated serum CA19-9 may be associated with pulmonary sequestration.
- Pulmonary sequestration should be considered in the differential diagnosis of unexplained hyper-CA19-9 levels.
- Further research is warranted to understand the mechanism linking pulmonary sequestration and CA19-9 elevation.
Abstract:
This report presents two young women were admitted to the department of thoracic surgery, Beijng Chao-Yang Hospital because of the extremely elevation of the serum Carbohydrate antigen 19-9 (CA19-9). The enhanced Computed Tomography scan showed that the lesion of the lung and the anomalous artery, and diagnosis of the pulmonary sequestration was made. The positron emission tomography/computed tomography (PET/CT) scan was taken to exclude any kind of malignant tumor. Both of them had the lobectomy operation confirmed our preoperative diagnosis. After the operation, the serum level of CA19-9 decreased to normal range rapidly. Therefore, in these two cases, the markedly elevation of serum CA19-9 level may have resulted from the pulmonary sequestration.
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