Related Experiment Video

Updated: Mar 12, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

4.4K

Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study

T Honek, J Krejci, J Machal

    Bratislavske Lekarske Listy
    |November 10, 2016
    PubMed

    Insights

    Alcohol septal ablation (ASA) significantly improves left ventricular outflow tract gradient and functional status in hypertrophic obstructive cardiomyopathy (HOCM) patients compared to conservative treatment.

    Area of Science:

    • Cardiology
    • Interventional Cardiology

    Background:

    • Hypertrophic obstructive cardiomyopathy (HOCM) presents challenges in managing left ventricular outflow tract obstruction and functional decline.
    • Conservative management offers limited symptomatic relief for HOCM patients.

    Purpose of the Study:

    • To compare the long-term echocardiographic parameters and functional status in HOCM patients undergoing alcohol septal ablation (ASA) versus conservative treatment.
    • To evaluate the impact of ASA on left ventricular remodeling and patient outcomes.

    Main Methods:

    • Prospective study comparing 41 HOCM patients treated conservatively with 39 HOCM patients treated with ASA.
    • Echocardiographic parameters, including left ventricular outflow tract gradient (LVOTG), and New York Heart Association (NYHA) class were assessed over five years.

    Main Results:

    • ASA significantly reduced LVOTG at one and five years post-procedure compared to conservative treatment (p<0.001 and p<0.05, respectively).
    • Patients in the ASA group showed a significant improvement in NYHA class at one, three, and five years compared to the conservative group (all p<0.001).
    • A decline in LVOTG after ASA was associated with favorable left ventricle remodeling.

    Conclusions:

    • Alcohol septal ablation is superior to conservative treatment in improving functional status and reducing LVOTG in HOCM patients.
    • ASA promotes beneficial left ventricular remodeling, leading to sustained functional improvement in HOCM.
    • This study provides evidence for ASA as an effective interventional option for HOCM.
    Abstract

    Keywords:
    alcohol septal ablationconservative treatmenthypertrophic obstructive cardiomyopathyinvasive treatment echocardiography.

    More Related Videos

    Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

    Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

    Published on: July 14, 2021

    5.6K
    A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats07:31

    A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

    Published on: December 2, 2016

    10.8K

    Related Concept Videos

    Cardiomyopathy V: Interprofessional Care01:29

    Cardiomyopathy V: Interprofessional Care

    Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
    571
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    607
    Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

    Cardiomyopathy VII: Pre and Post Operative Nursing Management

    Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
    410
    Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

    Cardiomyopathy IV: Restrictive Cardiomyopathy

    Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
    714
    Cardiomyopathy II: Dilated Cardiomyopathy01:30

    Cardiomyopathy II: Dilated Cardiomyopathy

    Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
    700
    Mitral Stenosis III: Medical Management01:26

    Mitral Stenosis III: Medical Management

    Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
    408