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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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[Hypertension due to fibromuscular dysplasia: look for additional disease sites]

M L Maas1, J M Kroese, S J H Bredie

  • 1Radboudumc, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|November 10, 2016
PubMed

Insights

Fibromuscular dysplasia (FMD) is a vascular condition affecting arteries. Treatment like percutaneous angioplasty of the renal arteries (PTRA) can normalize blood pressure in some patients with renal artery stenosis.

Area of Science:

  • Vascular Medicine
  • Nephrology
  • Cardiology

Background:

  • Fibromuscular dysplasia (FMD) is a non-inflammatory vasculopathy affecting arteries.
  • Renal artery stenosis due to FMD can cause renovascular hypertension.
  • Cervical FMD is often comorbid and poses stroke risks.

Purpose of the Study:

  • To discuss diagnostic and therapeutic options for FMD.
  • To highlight the interplay between renovascular and cervical FMD.
  • To emphasize the need for prospective studies.

Main Methods:

  • Case study review of patients with renovascular and cervical FMD.
  • Discussion of current diagnostic modalities.
  • Review of therapeutic interventions including percutaneous angioplasty of the renal arteries (PTRA).

Main Results:

  • PTRA normalizes blood pressure in 45% of patients with FMD-related renal artery stenosis.
  • Younger patients and those with shorter hypertension history show better PTRA outcomes.
  • Comorbid cervical FMD increases risk for stroke.

Conclusions:

  • FMD management requires a comprehensive approach considering both renal and cervical involvement.
  • PTRA is an effective treatment for renovascular hypertension in select FMD patients.
  • Further prospective research is crucial for optimizing FMD diagnosis and treatment strategies.

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