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Related Concept Videos

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

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Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
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[Domperidone to promote lactation].

N van Paassen1, A M van der Starre, L M Hanff

  • 1Erasmus MC, Rotterdam.

Nederlands Tijdschrift Voor Geneeskunde
|November 10, 2016
PubMed
Summary

Domperidone can be considered for low breast milk production when other methods fail. Prescribed at low doses, it poses minimal risk to newborns and low risk of maternal arrhythmias, allowing safe use by general practitioners.

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Area of Science:

  • Neonatal Medicine
  • Pharmacology

Background:

  • Breast milk is the optimal nutrition for newborns, particularly premature infants.
  • Insufficient breast milk production can necessitate interventions.
  • Lactation support and optimized feeding techniques are primary strategies.

Purpose of the Study:

  • To evaluate the safety and efficacy of domperidone for enhancing breast milk production.
  • To provide guidance on the appropriate use of domperidone in breastfeeding mothers.

Main Methods:

  • Review of existing literature on domperidone for lactation support.
  • Analysis of safety data regarding maternal and neonatal side effects.
  • Assessment of cardiac risks associated with domperidone, specifically QTc prolongation.

Main Results:

  • Domperidone is a viable option when conservative measures for insufficient milk supply are ineffective.
  • Neonatal side effects are negligible.
  • Maternal cardiac risks (arrhythmias due to QTc prolongation) are low with low-dose (10 mg tds) domperidone.
  • Routine ECG is not necessary for prescribing domperidone in the absence of risk factors.

Conclusions:

  • General practitioners can safely prescribe low-dose domperidone to mothers with insufficient breast milk production.
  • Treatment effectiveness should be assessed after two weeks.
  • ECG monitoring is recommended for prolonged use or higher dosages to rule out QTc prolongation.