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Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
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Mitochondrial Ca2+ uptake controls actin cytoskeleton dynamics during cell migration.

Julien Prudent1, Nikolay Popgeorgiev2, Rudy Gadet2

  • 1Medical Research Council, Mitochondrial Biology Unit, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.

Scientific Reports
|November 10, 2016
PubMed
Summary

Mitochondrial calcium (Ca2+) homeostasis, regulated by the Mitochondria Calcium Uniporter (MCU), is crucial for cell migration in mammals. Silencing MCU impairs cell movement by affecting cytoskeleton dynamics and focal adhesions.

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