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Updated: Mar 12, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Elevated expression of thyroid hormone receptor-interacting protein 13 drives tumorigenesis and affects clinical
Wang Dazhi1,2, Zhang Mengxi1, Chen Fufeng2
1Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.
Aim:
To investigate the expression of TRIP13 in multiple tumors and to evaluate the relationship between TRIP13 and survival of cancer patients.
Materials & Methods:
Sample expression profiles were downloaded from the gene expression omnibus database. Correlation between TRIP13 expression and clinicopathological features was analyzed by χ2 test. Patient survival was evaluated by Kaplan-Meier analysis.
Results:
TRIP13 expression was upregulated in 12 cancer types; it significantly correlated with multiple clinicopathological features of breast, liver and lung cancer. High TRIP13 expression indicated poor prognosis of patients with breast, liver, gastric and lung cancer.
Conclusion:
TRIP13 is highly expressed in multiple tumors and may be used as a potential prognostic marker and therapeutic target.
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