Selection of the appropriate parameter to measure neural regeneration

A rat sciatic nerve model of regeneration was assessed by multiple techniques to determine the relationship between parameters of neural regeneration in common use today. The results demonstrated significant correlation and internal consistency between electrophysiological and morphological parameters (i.e., conduction velocity and fiber diameter) but not necessarily a correlation between these physiological parameters and overall nerve function as assessed by a modified walking track technique. Guidelines for parameter selection are suggested based upon the specific question being investigated (e.g., sensory and/or motor function versus axoplasmic flow and/or neurotropism) rather than the nonspecific "neural regeneration."