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Ventral abdominal wall defect correction in rats with contaminated meshes
Paola Zarur Varella1, Nicolau Gregori Czeczko2, Manoel Alberto Prestes3
1Fellow Master degree, Postgraduate Program in Principles of Surgery, Medical Research Institute, Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil. Technical procedures, design of the study, manuscript preparation.
Acta Cirurgica Brasileira
|November 10, 2016
Summary
This study found no significant difference between Marlex(r) and Dynamesh PP-light(r) meshes for abdominal wall defect repair in rats. Both meshes performed similarly in contaminated surgical sites, indicating comparable efficacy.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Wound Healing Research
Background:
- Abdominal wall defect repair often utilizes synthetic meshes.
- Assessing mesh performance in contaminated environments is crucial for patient safety.
- Marlex(r) and Dynamesh PP-light(r) are commonly used polypropylene meshes.
Purpose of the Study:
- To compare the efficacy of Marlex(r) and Dynamesh PP-light(r) meshes.
- To evaluate mesh performance in a contaminated surgical site model.
- To investigate potential differences in abdominal wall defect correction.
Main Methods:
- Twenty-eight Wistar rats were used, divided into two groups (Marlex(r) and Dynamesh PP-light(r)).
- Meshes were contaminated with Escherichia coli prior to implantation.
- Macroscopic, microscopic, and microbiological analyses were performed on abdominal wall tissues.
Main Results:
- No statistical significance was found in macroscopic variables between the mesh groups.
- An accentuated inflammatory process was observed in all subgroups.
- Microbiological analysis showed similar results for both meshes in the contaminated site.
Conclusions:
- Marlex(r) and Dynamesh PP-light(r) meshes demonstrated comparable outcomes in abdominal wall defect repair.
- Neither mesh showed a significant advantage in the contaminated surgical site model.
- Further research may explore long-term outcomes and different contamination levels.
