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One-anastomosis Gastric Bypass OAGB in Rats
Published on: November 10, 2018
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Vertical gastrectomy in overweight and non-overweight rats
Fernando Issamu Tabushi1, Melissa Spena Stueber2, Benur Polonio3
1PhD, Associate Professor, Postgraduate Program in Principles of Surgery, Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil. Intellectual and scientific content of the study; technical procedures; acquisition, analysis and interpretation of data; manuscript writing.
Acta Cirurgica Brasileira
|November 10, 2016
Summary
Sleeve-like gastrectomy outcomes were similar in overweight and normal-weight rats, regardless of total or seromuscular suture lines. This study found no significant differences in complications or recovery between the groups.
Area of Science:
- Surgical innovation
- Gastroenterology
- Obesity research
Background:
- Partial gastrectomy is a common surgical procedure.
- Obesity can impact surgical outcomes and healing.
- Understanding suture line efficacy in different weight classes is crucial.
Purpose of the Study:
- To compare the efficacy of total versus seromuscular suture lines after partial gastrectomy.
- To evaluate surgical outcomes in normal and overweight rat models.
Main Methods:
- Forty Wistar rats were divided into normal diet and overweight (saccharose-supplemented) groups.
- Sleeve-like gastrectomy with total or seromuscular gastrorrhaphy was performed.
- Postoperative outcomes including mortality, morbidity, biochemical markers, and tissue analysis were assessed.
Main Results:
- Overweight rats exhibited increased body weight and greater gonadal/retroperitoneal fat accumulation.
- No significant differences in mortality or clinical complications were observed between groups.
- Biochemical differences in urea, albumin, total cholesterol, and bilirubin were noted in the overweight group.
Conclusions:
- Both total and seromuscular suture lines demonstrated comparable safety and efficacy in sleeve-like gastrectomy.
- Rat body weight did not significantly influence the outcomes of gastric suture repair.
