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Updated: Mar 12, 2026
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
ANTIMICROBIAL SUSCEPTIBILITY OF Streptococcus agalactiae ISOLATED FROM PREGNANT WOMEN
Simone Cristina Castanho Sabaini de Melo1, Nathally Claudiane de Souza Santos2, Marcia de Oliveira2
1State University of Maringá, Postgraduate Program in Health Sciences Maringá, Paraná, Brazil. E-mails: simonecastanho@uenp.edu.br; mdbcarvalho@gmail.com; smpelloso@gmail.com or smpelloso@uem.br.
Insights
Group B Streptococcus (GBS) is a risk for newborns. In Brazil, GBS isolates from pregnant women remained susceptible to penicillin, but resistance to clindamycin and erythromycin was observed, limiting alternative treatments.
Area of Science:
- Microbiology
- Obstetrics
- Infectious Diseases
Background:
- Group B Streptococcus (GBS), or Streptococcus agalactiae, colonizes the gastrointestinal and genitourinary tracts.
- GBS is a significant risk factor for neonatal disease.
Purpose of the Study:
- To evaluate the antimicrobial susceptibility of GBS isolates from pregnant women in Northern Paraná, Brazil.
- To inform intrapartum antibiotic prophylaxis strategies.
Main Methods:
- A descriptive, analytical, cross-sectional study was conducted.
- Antimicrobial susceptibility testing was performed on 136 GBS isolates from 544 pregnant women (≥ 35 weeks gestation).
Main Results:
- All GBS isolates demonstrated susceptibility to penicillin, the primary drug for intrapartum prophylaxis.
- Resistance to clindamycin and erythromycin was detected in a subset of isolates.
Conclusions:
- Penicillin remains a reliable option for GBS prophylaxis in this population.
- Decreased susceptibility to clindamycin and erythromycin reduces alternative prophylaxis options for penicillin-allergic women.
- Further research is needed to understand GBS sensitivity profiles in other regions.
Introduction::
Group B streptococcus (GBS) or Streptococcus agalactiae can colonize the gastrointestinal and genitourinary tracts and has been considered one of the most important risk factors for the development of neonatal disease. The present study evaluated the antimicrobial susceptibility of GBS isolates from pregnant women who were attended at a public health service in Northern Paraná, Brazil.
Methods::
A descriptive analytical cross-sectional study was performed with 544 pregnant women, at ≥ 35 weeks of gestation. One hundred and thirty-six GBS isolates from pregnant women were tested for antimicrobial susceptibility.
Results::
All of the GBS isolates showed susceptibility to the drug that is most frequently used for intrapartum prophylaxis: penicillin. Resistance to clindamycin and erythromycin was detected, thus decreasing the options of prophylaxis in women who are allergic to penicillin.
Conclusions::
Additional studies should be conducted to increase the knowledge of GBS sensitivity profile to antimicrobials in other health centers.
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