Related Experiment Video
Updated: Mar 12, 2026
06:40
An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
Published on: June 8, 2021
3.0K
Perioperative Anesthesia Care and Tumor Progression
Mir W Sekandarzad1, André A J van Zundert, Philipp B Lirk
1From the *Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Herston-Brisbane, Queensland, Australia; and †Division of Anesthesiology, Intensive Care, Emergency Medicine, Pain Therapy and Palliative Care, University Medical Center Amsterdam, Amsterdam, the Netherlands.
Anesthesia and Analgesia
|November 10, 2016
Summary
Perioperative anesthesia care bundles impact tumor progression. While regional anesthesia data is inconclusive, local anesthetics show anti-tumor effects, and NSAIDs and opioids are beneficial for multimodal analgesia.
Area of Science:
- Anesthesiology
- Oncology
- Surgical Care
Background:
- Perioperative anesthesia care bundles are crucial in cancer surgery.
- The impact of anesthesia on tumor progression and recurrence is an evolving area of research.
Purpose of the Study:
- To critically appraise current literature on perioperative anesthesia factors and their effect on tumor progression.
- To evaluate the role of local anesthetics, opioids, NSAIDs, and anesthetic agents in cancer recurrence.
Main Methods:
- Narrative review of recent findings and systematic reviews.
- Analysis of basic science data and preclinical/clinical studies.
Main Results:
- Regional anesthesia data for cancer recurrence is inconclusive.
- Local anesthetics demonstrate anti-tumor effects.
- Opioids are safe for perioperative pain management; NSAIDs are essential for multimodal analgesia.
- Volatile anesthetics may increase tumor formation; propofol shows tumor-protective qualities.
Conclusions:
- Balanced anesthesia incorporating regional techniques, NSAIDs, opioids, and local anesthetics is essential.
- These strategies aim to mitigate the pathophysiologic effects of pain and neuroendocrine stress response during the perioperative period in cancer patients.
Related Concept Videos
01:24General Anesthesia: Overview
923
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
923
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
410
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
410
01:22Stages of General Anesthesia
2.1K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
2.1K
01:22Aneurysm IV: Nursing Management
563
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
563
01:24Parenteral Anesthetics: Overview
851
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
851
01:23Peripheral Artery Disease V: Postoperative Nursing Management
506
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
506