Related Experiment Video
Updated: Mar 12, 2026
11:12
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
1.0K
Metabolic Signaling Drives IFN-γ
Peter J Siska1, Jeffrey C Rathmell1
1Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA.
Cell Metabolism
|November 10, 2016
Summary
Interferon-gamma (IFN-γ), a key inflammatory cytokine, is linked to cellular metabolism through glycolysis. This study reveals that acetyl-CoA maintenance and epigenetic regulation of the IFNG gene are crucial for this connection.
Area of Science:
- Immunology
- Cellular Metabolism
- Epigenetics
Background:
- Interferon-gamma (IFN-γ) is a vital inflammatory cytokine.
- IFN-γ production is closely linked to cellular metabolic status, particularly high rates of glycolysis.
- Understanding the molecular mechanisms connecting IFN-γ regulation and cellular metabolism is crucial.
Purpose of the Study:
- To elucidate the key mechanisms linking IFN-γ production to cellular metabolic status.
- To investigate the role of acetyl-CoA and epigenetic modifications in regulating the IFNG gene locus.
Main Methods:
- Analysis of cellular metabolic pathways.
- Investigation of acetyl-CoA levels.
- Epigenetic analysis of the IFNG locus.
Main Results:
- A critical link between IFN-γ and cellular metabolism, specifically glycolysis, was identified.
- Maintenance of acetyl-CoA levels was shown to be essential for this metabolic regulation.
- Epigenetic regulation of the IFNG gene locus was demonstrated as a key mechanism.
Conclusions:
- Acetyl-CoA maintenance and epigenetic regulation of the IFNG locus are key mechanisms connecting IFN-γ to cellular metabolic status.
- These findings provide novel insights into the interplay between inflammation and cellular metabolism.
More Related Videos
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
10.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
10.2K
02:26NF-kB-dependent Signaling Pathway
2.4K
2.4K
01:20The JAK-STAT Signaling Pathway
13.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.6K
01:16TGF - β Signaling Pathway
10.8K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K
01:19Interactions Between Signaling Pathways
7.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
01:26Signal Transduction: Overview
12.3K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...
12.3K