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Published on: May 16, 2019
Behavioral health in young adults with epilepsy: Implications for transition of care
Janelle L Wagner1, Dulaney A Wilson2, Tanja Kellermann3
1College of Nursing, Medical University of South Carolina, United States; Comprehensive Epilepsy Program, Medical University of South Carolina, United States; Department of Pediatrics, Medical University of South Carolina, United States.
Insights
Young adults with epilepsy face significantly higher risks for neurodevelopmental and behavioral health disorders compared to those with migraine or fractures. This highlights a critical need for specialized care during the transition to adulthood.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Epilepsy is frequently associated with neurodevelopmental and behavioral health disorders.
- The specific risks for young adults with epilepsy remain largely uncharacterized.
Purpose of the Study:
- To determine the prevalence and risk factors of neurodevelopmental and behavioral health comorbidities in young adults with epilepsy.
- To compare these risks against young adults with migraine and healthy controls.
Main Methods:
- A case-control study design was employed, analyzing hospital admission, outpatient, and emergency department data.
- Participants included young adults (19-25 years) diagnosed with epilepsy, migraine, or lower extremity fracture (LEF).
- Statistical analysis involved univariate and multivariate polytomous logistic regression to assess comorbidity associations.
Main Results:
- Young adults with epilepsy exhibited higher proportions of behavioral health comorbidities (51.8%) than migraine (37.6%) or LEF (21.6%) groups.
- Epilepsy was associated with a 76% increased risk of behavioral health and a 297% increased risk of neurodevelopmental comorbidities compared to migraine.
- Adjusted analyses confirmed significantly higher odds of all behavioral health comorbidities in young adults with epilepsy.
Conclusions:
- Young adults with epilepsy are highly susceptible to neurodevelopmental and behavioral health disorders.
- Findings underscore the importance of addressing these comorbidities during the transition from pediatric to adult healthcare systems.
Aim:
Neurodevelopmental and behavioral health disorders commonly occur with epilepsy, yet risk for young adults is unknown. The aim of this study was to determine the distribution and risk characteristics of neurodevelopmental and behavior health comorbidities among young adults with epilepsy compared with those among young adults with migraine and healthy controls.
Method:
A case-control study examining hospital admission, outpatient, and emergency department (ED) visits for young adults with an ICD-9-CM diagnosis of epilepsy, migraine, or lower extremity fracture (LEF) was conducted. The association of epilepsy, migraine, or LEF with comorbidities was evaluated with univariate and multivariate polytomous logistic regression.
Results:
From 2000 to 2013, 29,139 young adults ages 19 to 25years were seen in hospitals and EDs for epilepsy (5666), migraine (17,507), or LEF (5966). Young adults with epilepsy had higher proportions of behavioral health comorbidities (51.8%) compared with controls with migraine (37.6%) or LEF (21.6%). In young adults with epilepsy compared with migraine, the increased risk of having any behavioral health comorbidity was 76%, and neurodevelopmental comorbidity was 297%. After adjustment, young adults with epilepsy showed significantly higher odds of each behavioral health comorbidity compared with controls with migraine and LEF.
Interpretation:
Young adults with epilepsy are particularly susceptible to behavioral health and neurodevelopmental disorders. Results are discussed within the context of transition to adult care.
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