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Aromatherapy for the treatment of PONV in children: a pilot RCT
Mathew B Kiberd1, Suzanne K Clarke2, Jill Chorney2,3,4
1Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 1276 South Park Street, 231-C 10 West Victoria Building, Halifax, NS, B3H 2Y9, Canada. Mathew.kiberd@dal.ca.
Insights
Aromatherapy showed a small, non-significant effect on pediatric postoperative nausea and vomiting (PONV). A large-scale trial is not feasible, suggesting limited utility for this intervention in children.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Complementary Medicine
Background:
- Postoperative nausea and vomiting (PONV) is a common complication in pediatric patients following general anesthesia.
- Aromatherapy has demonstrated efficacy in managing PONV in adult populations.
- This study investigated the feasibility of a large-scale trial on aromatherapy for pediatric PONV.
Purpose of the Study:
- To assess the effectiveness of aromatherapy in reducing postoperative nausea and vomiting in children.
- To determine the feasibility of conducting a large-scale randomized controlled trial (RCT) for pediatric PONV using aromatherapy.
- To evaluate the impact of aromatherapy on nausea scores, antiemetic use, and emesis in pediatric patients.
Main Methods:
- A pilot randomized controlled trial was conducted on 41 pediatric patients (ages 4-16) undergoing ambulatory surgery.
- Nausea was assessed using the Baxter Retching Faces (BARF) scale, with a clinically significant reduction defined as a two-point decrease.
- Patients with nausea were randomized to receive either saline placebo or aromatherapy (QueaseEase™).
Main Results:
- Aromatherapy demonstrated a small, non-significant effect size (Eta 0.175) compared to placebo for the primary outcome.
- No significant differences were observed in antiemetic use (P=.75) or emesis (P=.87) between groups.
- A statistically significant difference was found in continued intervention use (P=.048), with higher adherence in the aromatherapy group.
Conclusions:
- Aromatherapy exhibited a minimal, non-significant effect on pediatric PONV.
- A large-scale RCT is deemed not feasible and of doubtful utility at this institution.
- Further research may be needed to explore alternative interventions or refine aromatherapy protocols for pediatric PONV.
Background:
Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications of general anesthesia in pediatrics. Aromatherapy has been shown to be effective in treating PONV in adults. Given the encouraging results of the adult studies, we planned to determine feasibility of doing a large-scale study in the pediatric population.
Methods:
Our group conducted a pilot randomized controlled trial examining the effect of aromatherapy on post-operative nausea and vomiting in patients 4-16 undergoing ambulatory surgery at a single center. Nausea was defined as a score of 4/10 on the Baxter Retching Faces Scale (BARF scale). A clinically significant reduction was defined as a two-point reduction in Nausea. Post operatively children were administered the BARF scale in 15 min internals until discharge home or until nausea score of 4/10 or greater. Children with nausea were randomized to saline placebo group or aromatherapy QueaseEase™ (Soothing Scents, Inc, Enterprise, AL: blend of ginger, lavender, mint and spearmint). Nausea scores were recorded post intervention.
Results:
A total of 162 subjects were screened for inclusion in the study. Randomization occurred in 41 subjects of which 39 were included in the final analysis. For the primary outcome, 14/18 (78 %) of controls reached primary outcome compared to 19/21 (90 %) in the aromatherapy group (p = 0.39, Eta 0.175). Other outcomes included use of antiemetic in PACU (control 44 %, aromatherapy 52 % P = 0.75, Eta 0.08), emesis (Control 11 %, 9 % aromatherapy, P = 0.87, Eta = 0.03). There was a statistically significant difference in whether subjects continued to use the intervention (control 28 %, aromatherapy 66 %, p-value 0.048, Eta 0.33).
Conclusion:
Aromatherapy had a small non-significant effect size in treating postoperative nausea and vomiting compared with control. A large-scale randomized control trial would not be feasible at our institution and would be of doubtful utility.
Trial Registration:
ClinicalTrials.gov NCT02663154 .
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