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Arterial Stiffness Is Significantly Associated With Left Ventricular Diastolic Dysfunction in Patients With

Takayuki Namba1, Nobuyuki Masaki, Yuki Matsuo

  • 1Department of Cardiology, National Defense Medical College.

International Heart Journal
|November 11, 2016
PubMed

Insights

Arterial stiffness, measured by cardio-ankle vascular index (CAVI), is independently linked to left ventricular (LV) diastolic dysfunction in cardiovascular disease patients. This suggests stiffness contributes to diastolic dysfunction, a key factor in heart failure with preserved ejection fraction (HFpEF).

Area of Science:

  • Cardiology
  • Vascular Biology
  • Heart Failure Research

Background:

  • Left ventricular (LV) diastolic dysfunction is a primary driver of heart failure with preserved ejection fraction (HFpEF).
  • The relationship between arterial stiffness and LV diastolic dysfunction in patients with established cardiovascular disease requires further investigation.

Purpose of the Study:

  • To investigate the association between arterial stiffness, assessed by cardio-ankle vascular index (CAVI), and LV diastolic dysfunction in patients with clinical cardiovascular disease.

Main Methods:

  • A cross-sectional study included 100 patients diagnosed with cardiovascular disease (excluding reduced ejection fraction and valvular disease).
  • Arterial stiffness was measured using CAVI.
  • LV diastolic dysfunction was evaluated using echocardiography, specifically the ratio of early diastolic transmitral flow velocity to early diastolic mitral annular velocity (E/e').

Main Results:

  • Patients with higher CAVI values exhibited significantly higher E/e' ratios compared to those with lower CAVI values, both in the overall cohort and in the heart failure subgroup.
  • Univariate and multivariate regression analyses confirmed that CAVI was an independent predictor of E/e', indicating a significant association between arterial stiffness and LV diastolic dysfunction.

Conclusions:

  • Elevated arterial stiffness, indicated by a high CAVI, is independently associated with left ventricular diastolic dysfunction in patients presenting with clinical cardiovascular disease.
  • These findings highlight the potential role of arterial stiffness as a contributing factor to the development and progression of LV diastolic dysfunction.

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