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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Myocarditis III: Medical Management01:14

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Periodontitis and myocardial hypertrophy.

Jun-Ichi Suzuki1, Hiroki Sato2, Makoto Kaneko2

  • 1Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
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Summary

Periodontitis, a gum disease, is linked to heart conditions like myocardial hypertrophy. Understanding this connection may help treat heart disease by managing chronic inflammation.

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Area of Science:

  • Cardiology
  • Periodontology
  • Immunology

Background:

  • Clinical observations suggest a link between periodontitis severity and left ventricular hypertrophy.
  • The precise mechanisms connecting periodontitis and myocardial hypertrophy remain unclear.

Purpose of the Study:

  • To investigate the pathophysiological mechanisms linking periodontal infections to myocardial hypertrophy.
  • To explore the role of specific periodontal pathogens in cardiac remodeling.

Main Methods:

  • Utilized murine transverse aortic constriction models to study cardiac hypertrophy.
  • Employed isoproterenol-induced myocardial hypertrophy models.
  • Investigated the involvement of Toll-like receptor-2 signaling.

Main Results:

  • Aggregatibacter actinomycetemcomitans infection enhanced cardiac hypertrophy and matrix metalloproteinase-2 activation in a murine model.
  • Porphyromonas gingivalis infection induced myocardial hypertrophy via Toll-like receptor-2 signaling in a separate model.
  • Chronic inflammation from periodontitis appears crucial in myocardial hypertrophy development.

Conclusions:

  • Periodontal bacteria infection is closely associated with myocardial hypertrophy.
  • Targeting chronic inflammation in periodontitis may be a therapeutic strategy for myocardial hypertrophy.
  • Further research into the interplay between oral health and cardiovascular disease is warranted.