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[Amiodarone keratopathy. Prospective longitudinal study]
M C Castañón Romo1, O Santander Juárez, R Chávez Domínguez
1Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Archivos Del Instituto De Cardiologia De Mexico
|May 1, 1989
Summary
Age significantly influences corneal micro-deposits from amiodarone, with older patients showing higher accumulation. This study investigated amiodarone deposits in 150 patients, finding age as the primary determinant factor.
Area of Science:
- Ophthalmology
- Pharmacology
Context:
- Amiodarone is an antiarrhythmic drug known to cause ocular side effects.
- Corneal micro-deposits are a common finding in patients treated with amiodarone.
Purpose:
- To determine the frequency of amiodarone-induced corneal micro-deposits.
- To investigate the relationship between these deposits and patient age, sex, dose, and treatment duration.
Summary:
- 150 patients treated with amiodarone were examined for corneal micro-deposits.
- 114 patients (76%) exhibited deposits, with density correlating directly with age.
- Other ocular findings included lens pigment deposits, atypical keratopathy, blepharitis, and conjunctivitis.
Impact:
- Age is a significant determinant factor for corneal micro-deposit accumulation from amiodarone.
- Findings contribute to understanding amiodarone's ocular toxicity profile.
- Highlights the importance of regular ophthalmic monitoring in amiodarone users.