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Published on: October 15, 2014
Propionibacterium acnes: Time-to-Positivity in Standard Bacterial Culture From Different Anatomical Sites
Rasha Abdulmassih1, Jina Makadia1, James Como1
1Division of Infectious Diseases, Allegheny General Hospital, 420 East North Ave., Pittsburgh, PA 15212, USA.
Background:
Propionibacterium acnes infections are likely under-recognized and underreported. This is partly because of low clinical suspicion, perceived non-pathogenicity, or lack of adequate culture incubation time. We conducted a study to assess the optimal incubation period to recover P. acnes from specimens acquired during the workup of suspected clinical infections.
Methods:
A 5-year retrospective chart review was conducted between January 2010 and December 2014 at a single tertiary-care hospital. All patient cases from which P. acnes was recovered were included for analysis. Source of infection, antibiotic use, and culture time-to-positivity (TTP) were recorded.
Results:
Implanted devices comprised the single most common source of P. acnes infection. In the majority of cases, P. acnes was the only organism identified. The mean incubation TTP for all isolates was 5.73 days.
Conclusions:
Standard 5-day culture incubation periods are insufficient to recover P. acnes. As a result, P. acnes is likely a much more common etiology of a variety of clinical infections than previously reported.
