Scrotal Involvement with Testicular Nonseminomatous Germ Cell Tumour

Area of Science:

• Oncology
• Urology
• Pathology

Background:

• Testicular germ cell tumors (GCTs) rarely involve the scrotum due to distinct embryonic origins.
• Atypical presentations of GCTs necessitate careful diagnostic and management strategies.

Purpose of the Study:

• To report a case of nonseminomatous germ cell tumor (NSGCT) with extensive scrotal involvement.
• To discuss the management and outcomes of such rare presentations.

Main Methods:

• Surgical intervention including bilateral orchidectomy and hematoma evacuation.
• Chemotherapy regimen: bleomycin, etoposide, and cisplatin (BEP).
• Tumor marker monitoring (AFP, HCG, LDH) and staging investigations (CT scans).

Main Results:

• Complete tumor resolution achieved after 4 cycles of BEP chemotherapy.
• Normalization of tumor markers after 3 cycles of treatment.
• Histological confirmation of no malignant tissue post-treatment, despite initial positive margins and scrotal involvement.

Conclusions:

• Timely and appropriate treatment can lead to complete remission even in rare GCT cases with significant scrotal involvement.
• Atypical presentations of testicular cancer require individualized management approaches.
• Long-term complications such as hormonal deficiency and infertility should be considered.