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Findings from the Section on Bioinformatics and Translational Informatics.

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    This review highlights top 2015 research in bioinformatics and translational informatics, focusing on managing large genomic datasets for clinical care and personalized medicine.

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    Area of Science:

    • Bioinformatics and Translational Informatics
    • Genomic Medicine
    • Health Informatics

    Background:

    • The field of Bioinformatics and Translational Informatics is rapidly evolving.
    • Application in health domain and clinical care is a key focus.
    • The IMIA Yearbook aims to synthesize current research and future trends.

    Purpose of the Study:

    • To summarize excellent current research published in 2015 in Bioinformatics and Translational Informatics.
    • To propose a selection of best papers with applications in health and clinical care.
    • To provide an overview of current and future activities in the field.

    Main Methods:

    • A systematic literature search using MEDLINE with specific keywords.
    • Evaluation of 1,566 articles by section editors.
    • Selection of 14 articles for peer-review and inclusion in the IMIA Yearbook 2016.

    Main Results:

    • Four excellent articles were selected, focusing on data management of large-scale datasets and genomic medicine.
    • Three articles highlighted the potential of re-analyzing existing data, such as from The Cancer Genome Atlas (TCGA).
    • One article presented an original analysis of genomic data from sub-Saharan African populations.

    Conclusions:

    • Research in Bioinformatics and Translational Informatics focuses on new algorithms and statistical models for large-scale genomic data.
    • Interpreting genomic data is crucial for clinical translation, precise diagnostics, and personalized medicine.
    • Efforts are ongoing to bridge the gap between genomic discoveries and clinical applications.