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Subareolar Sclerosing Ductal Hyperplasia.
Esther Cheng1,2, Timothy M D'Alfonso1,2, Maria Arafah3
11 Weill Cornell Medicine, New York, NY, USA.
International Journal of Surgical Pathology
|November 11, 2016
Summary
Subareolar sclerosing duct hyperplasia (SSDH) is a breast condition characterized by hyperplasia and sclerosis. Long-term follow-up is recommended, as ductal carcinoma in situ can develop later.
Area of Science:
- Breast pathology
- Sclerosing lesions
- Ductal hyperplasia
Background:
- Subareolar sclerosing duct hyperplasia (SSDH) requires further characterization.
- SSDH presents as a unilateral solitary lesion, typically in postmenopausal women.
Purpose of the Study:
- To review cases of SSDH and analyze associated lesions and long-term outcomes.
- To assess the recurrence and subsequent development of significant lesions in patients with SSDH.
Main Methods:
- Retrospective review of 35 SSDH cases diagnosed between 2000 and 2015.
- Analysis of patient demographics, lesion characteristics, concurrent pathologies, and follow-up data.
Main Results:
- SSDH cases showed florid epithelial hyperplasia with dense sclerosis.
- Concurrent significant lesions included low-grade adenosquamous carcinoma, DCIS, LCIS, and ADH.
- No SSDH recurrence was observed, but 6 patients developed subsequent lesions, including DCIS and ADH.
Conclusions:
- SSDH is associated with various significant breast lesions.
- Long-term surveillance is crucial for patients with SSDH due to the risk of subsequent DCIS development.
