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[Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from

Long Davalos1, Yessica Terrazas1,2, Ana Quintana1,2

  • 1Universidad Peruana Cayetano Heredia. Lima, Perú.

Revista Peruana De Medicina Experimental Y Salud Publica
|November 11, 2016
PubMed

Insights

Pneumococcal meningitis is a deadly disease in young children, with most deaths occurring within 48 hours. Prompt diagnosis, management, and pneumococcal vaccination are critical for prevention and survival.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Pneumococcal meningitis remains a significant cause of mortality in children.
  • Understanding its clinical features and antibiotic resistance patterns is crucial for effective treatment.

Purpose of the Study:

  • To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru.

Main Methods:

  • A case series of 44 pneumococcal meningitis episodes in children under 16 years old.
  • Data collected from two prospective, multicenter, passive surveillance studies in Lima, Peru (2006-2011).

Main Results:

  • The overall case fatality rate was 32.6%, significantly higher in children under 2 years old.
  • Malnutrition was associated with fatal cases. Antibiotic resistance was observed for penicillin, ceftriaxone, and chloramphenicol.
  • Common serotypes included 6B, 14, 19F, and 23F, with 84.1% being PCV13 serotypes.

Conclusions:

  • Pneumococcal meningitis is particularly lethal in infants, with rapid progression to death in many cases.
  • Prompt diagnosis, management, and pneumococcal vaccination are essential to reduce mortality.
Abstract

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