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Executive function in pediatric patients with cystic fibrosis, inflammatory bowel disease and in healthy controls

B Piasecki1, R Turska-Malińska, T Matthews-Brzozowska

  • 1Department of Clinical Psychology, Poznan University of Medical Sciences, Poznan, Poland. bpiasecki@ump.edu.pl.

European Review for Medical and Pharmacological Sciences
|November 11, 2016
PubMed

Insights

Pediatric patients with cystic fibrosis (CF) show executive function deficits compared to healthy children and those with inflammatory bowel disease (IBD). This study is the first to report these CF-related cognitive impairments.

Area of Science:

  • Neuroscience
  • Pediatric Medicine
  • Psychology

Background:

  • Executive function is crucial for daily activities.
  • Pediatric chronic illnesses like cystic fibrosis (CF) and inflammatory bowel disease (IBD) may impact cognitive development.
  • Limited research exists on executive function in pediatric CF and IBD populations.

Purpose of the Study:

  • To compare executive function performance in children with CF, IBD, and healthy controls.
  • To identify potential cognitive deficits associated with CF and IBD in pediatric patients.
  • To establish a baseline for cognitive functioning in these patient groups.

Main Methods:

  • The study included 28 pediatric patients with CF, 30 with IBD, and 30 healthy controls (ages 7-17).
  • All participants were within the intellectual norm range.
  • Executive functions were assessed using the Wisconsin Card Sorting Test (WCST).

Main Results:

  • Pediatric patients with CF demonstrated significantly poorer performance on multiple WCST indicators compared to both healthy controls and IBD patients (p < 0.05).
  • Specific deficits in CF patients included more errors, fewer conceptual level responses, and longer time to complete categories.
  • No significant executive function differences were found between the IBD group and the healthy control group.

Conclusions:

  • This study provides the first evidence of executive function deficits in pediatric patients with cystic fibrosis.
  • It also presents the initial description of executive function performance in pediatric IBD patients.
  • The findings highlight the need for cognitive assessment and support in children with CF.
Abstract

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