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Immunomodulation by the new synthetic thiazole derivative tiprotimod. 1st communication: synthesis and
K Fleischmann1, K H Scheunemann, H U Schorlemmer
1Research Laboratories of Pharma Research, Frankfurt Main, Fed. Rep. of Germany.
Arzneimittel-Forschung
|July 1, 1989
Abstract:
A series of carboxyalkylthio-substituted thiazole-carboxylic acids was synthesized and examined for macrophage activation and stimulation of the DTH (delayed type of hypersensitivity)-reaction. The structure-activity relationship in this series of new immunomodulators is discussed. Broadest immunological activity was seen for [2-(3-carboxy-1-propylthio)-4-methyl-1,3-thiazole]acetic acid (tiprotimod, HBW 538) which was selected for further studies.