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Are Epigenetic Factors Implicated in Chronic Widespread Pain?
Andrea Burri1,2,3, Zoya Marinova4, Mark D Robinson5,6
1Health and Rehabilitation Research Institute, Auckland University of Technology, Auckland, New Zealand.
Plos One
|November 11, 2016
Summary
This study identified three DNA methylation sites associated with chronic widespread pain (CWP). These findings may offer new insights into CWP mechanisms and potential treatments for this common condition.
Area of Science:
- Epigenetics
- Genetics
- Pain Research
Background:
- Chronic widespread pain (CWP) affects approximately 12% of the population and is a primary symptom of fibromyalgia.
- Heritability estimates suggest a 50% genetic contribution to CWP, indicating a genetic susceptibility.
- Exploring epigenetic modifications like DNA methylation is crucial for understanding CWP mechanisms.
Purpose of the Study:
- To investigate genome-wide differentially methylated positions (DMPs) associated with chronic widespread pain (CWP).
- To analyze epigenetic variations in unrelated individuals and discordant monozygotic twins.
- To identify potential epigenetic biomarkers for CWP.
Main Methods:
- Utilized a discovery sample of 281 individuals from the TwinsUK registry, including 33 discordant monozygotic (MZ) twins.
- Employed a replication sample of 1,485 individuals from the KORA S4 survey.
- Conducted epigenome-wide analysis of DNA methylation using the Illumina Infinium HumanMethylation 450 DNA BeadChip.
Main Results:
- Three CpG sites reached statistical significance in the replication sample: malate dehydrogenase 2 (MDH2), tetranectin (CLEC3B), and heat shock protein beta-6 (HSPB6).
- The identified loci (MDH2, CLEC3B, HSPB6) were associated with chronic widespread pain.
- Previously reported associations with COL1A2 and MAOB were not replicated in this study.
Conclusions:
- The findings provide a foundation for further research into DNA methylation and epigenetic mechanisms in CWP.
- Encourages large-scale investigations in independent cohorts to validate these epigenetic associations.
- Understanding epigenetic underpinnings of CWP could lead to novel therapeutic strategies and improved clinical management.
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