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Related Experiment Video

Updated: Mar 12, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Stromal Cell-Derived Factor 1 Polymorphism in Retinal Vein Occlusion.

Andrea Szigeti¹, Mónika Ecsedy¹, Miklós Schneider¹

¹Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

|November 11, 2016

Summary

The Stromal cell-derived factor 1 (SDF1)-3'A allele is associated with increased risk of neovascular complications in retinal vein occlusion (RVO). This genetic factor may play a role in the development of these ocular conditions.

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Published on: April 21, 2022

Area of Science:

Ophthalmology
Genetics
Molecular Biology

Background:

Stromal cell-derived factor 1 (SDF1) is implicated in angiogenesis and ocular neovascularization (NV).
Retinal vein occlusion (RVO) is a significant cause of vision loss, often associated with NV.

Purpose of the Study:

To investigate the association between the SDF1-3'G(801)A polymorphism and the occurrence of NV complications in patients with RVO.

Main Methods:

A case-control study involving 130 RVO patients (40 with NV, 90 without NV) and 125 controls.
Genotyping of the SDF1-3'G(801)A polymorphism was performed using PCR-RFLP.
Statistical analysis included chi-squared tests to compare allele and genotype frequencies.

Main Results:

The SDF1-3'G(801)A allele and genotype frequencies were similar between RVO patients and controls.
However, RVO patients with NV complications exhibited significantly higher frequencies of the SDF1-3'(801)AA and SDF1-3'(801)GA genotypes, and the SDF1-3'(801)A allele compared to those without NV and controls.
Carrying the SDF1-3'(801)A allele was associated with a 2.69-fold increased risk of developing NV complications in RVO.

Conclusions:

The SDF1-3'(801)A allele is a potential risk factor for the development of neovascular complications in retinal vein occlusion.
This finding highlights the role of specific genetic variations in the pathogenesis of RVO-related neovascularization.