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Updated: Mar 12, 2026
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
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Adhesion GPCR-Related Protein Networks.
1Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University of Mainz, Johannes von Muellerweg 6, Mainz, 55099, Germany.
Handbook of Experimental Pharmacology
|November 11, 2016
Summary
Adhesion G protein-coupled receptors (ADGRs) link cell adhesion and signaling. Understanding ADGR protein networks is key to developing new therapies for ADGR-related diseases.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Adhesion G protein-coupled receptors (ADGRs) integrate cell adhesion and signaling functions.
- ADGR protein networks are crucial for diverse cellular processes, including tissue polarity, cell migration, and immune responses.
- The large extracellular domains of ADGRs mediate cell-cell and cell-matrix interactions, while intracellular domains link to signaling pathways.
Purpose of the Study:
- To discuss the affiliation of ADGR networks with cellular modules and their regulation.
- To identify common features across networks associated with diverse ADGRs.
- To highlight the importance of deciphering ADGR protein complexes for therapeutic development.
Main Methods:
- Review of existing literature on ADGR protein networks and interactomes.
- Analysis of common features in ADGR-related protein networks across different cellular modules.
- Discussion of regulatory mechanisms governing ADGR networks.
Main Results:
- ADGR networks are integral to various cellular functions and are regulated through multiple mechanisms.
- Commonalities exist in the protein network compositions related to diverse ADGRs.
- Deciphering these networks reveals their essential role in preventing cellular damage.
Conclusions:
- Understanding ADGR protein network composition is crucial for comprehending their cellular roles.
- Detailed knowledge of ADGR interactomes can lead to the identification of novel therapeutic targets.
- Targeting ADGR networks holds promise for treating human diseases associated with these receptors.
Keywords:
ADGRAdhesion GPCRAdhesion complexesAffinity proteomicsBrain-specific angiogenesis inhibitorGPR98LatrophillinProtein networksSignaling pathwaysVLGR1More Related Videos
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