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Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis

Sheyu Li1, Jia Wei, Chenghui Zhang

  • 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|November 11, 2016
PubMed
Abstract

Insights

Circulating cell-derived microparticles (MPs) are elevated in type 2 diabetes mellitus (T2DM). Specifically, total MPs, platelet-derived MPs, monocyte-derived MPs, and endothelium-derived MPs are significantly higher in T2DM patients, suggesting their role in disease pathogenesis.

Area of Science:

  • Biomedical research
  • Endocrinology
  • Vascular biology

Background:

  • Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with significant global health implications.
  • Cell-derived microparticles (MPs) are small vesicles released from cell membranes, implicated in intercellular communication and various pathological processes.

Purpose of the Study:

  • To systematically review and meta-analyze the association between circulating cell-derived microparticles (MPs) and type 2 diabetes mellitus (T2DM).
  • To quantify differences in specific MP subtypes between T2DM patients and non-diabetic controls.

Main Methods:

  • Systematic literature search conducted in PubMed and Embase.
  • Inclusion of case-control and cross-sectional studies comparing MP levels in T2DM patients and controls.
  • Meta-analysis performed to calculate pooled standardized mean differences (SMDs) for various MP types.

Main Results:

  • Forty-eight studies with 2,460 T2DM patients and 1,880 controls were included.
  • Significantly elevated levels of circulating total MPs (TMPs), platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs), and endothelium-derived MPs (EMPs) were observed in T2DM patients compared to controls.
  • No significant difference in leukocyte-derived MPs (LMPs) was found between the groups.

Conclusions:

  • Circulating TMPs, PMPs, MMPs, and EMPs are elevated in individuals with T2DM.
  • Cell-derived MPs may contribute to the pathogenesis of type 2 diabetes mellitus.

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