Anaphylaxis to Over-the-Counter Flurbiprofen in a Child

Area of Science:

• Pediatric Allergy and Immunology
• Pharmacovigilance
• Drug Hypersensitivity

Background:

• Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly implicated in hypersensitivity reactions among pediatric populations.
• Over-the-counter (OTC) NSAIDs, including flurbiprofen, are widely accessible, raising concerns about potential adverse events.

Observation:

• This report details the first documented case of anaphylaxis to flurbiprofen in a pediatric patient.
• The clinical presentation underscores the potential for severe allergic reactions to commonly used OTC medications.

Findings:

• Flurbiprofen, an NSAID, can precipitate severe hypersensitivity reactions, including anaphylaxis, in susceptible children.
• A comprehensive allergy work-up is crucial for accurate diagnosis of drug-induced hypersensitivity.

Implications:

• Healthcare providers should be vigilant regarding the risk of anaphylaxis from OTC flurbiprofen in children.
• Establishing a definitive diagnosis through rigorous allergy assessment is essential for patient safety and management.
• Identifying safe alternative treatments is paramount for children with flurbiprofen hypersensitivity.