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Classic Kaposi's sarcoma - complete response to radiation therapy: a case report
Kennet Ramírez1, José Zavala2, David Morán3
1Departments of Radiation Oncology, State Oncology Center, Avenida Lázaro Cárdenas número 208, esquina antiguo camino a Chiná, sector Las Flores. Código Postal, 24096, Campeche, México. dr.kennet@hotmail.com.
Journal of Medical Case Reports
|November 12, 2016
Summary
This case study highlights successful radiation therapy for stage IV classic Kaposi's sarcoma in an HIV-negative patient. The treatment achieved complete clinical response, demonstrating its efficacy for this rare presentation.
Area of Science:
- Oncology
- Dermatology
- Radiation Oncology
Background:
- Classic Kaposi's sarcoma (KS) is a lymphatic endothelial neoplasm.
- While often associated with human immunodeficiency virus (HIV), KS can occur in HIV-negative individuals.
- Stage IV KS presents a significant clinical challenge, particularly in non-endemic regions.
Observation:
- A 78-year-old, HIV-negative Mexican man presented with widespread, painful skin lesions, including ulcerated feet.
- Biopsy confirmed classic Kaposi's sarcoma.
- The patient had extensive, stage IV disease.
Findings:
- Radiation therapy alone was administered, totaling 30 Gy in 15 fractions.
- Complete clinical response was achieved within 15 months of follow-up.
- The treatment demonstrated significant efficacy in local control and symptom palliation.
Implications:
- Radiation therapy can be an effective single-modality treatment for stage IV classic Kaposi's sarcoma in select HIV-negative patients.
- This case expands the understanding of KS treatment options beyond conventional approaches.
- The findings support radiation therapy for recurrence-free survival and palliation in advanced KS.
