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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Normal orbit skeletal changes in adolescents as determined through cone-beam computed tomography
B Lee1, C Flores-Mir1, M O Lagravère2,3
1Department of Dentistry, University of Alberta, Edmonton, Canada.
Adolescent orbital skeletal changes over 19-24 months were statistically significant but not clinically relevant. Cone-beam computed tomography (CBCT) analysis revealed average changes under 1mm, indicating minimal impact on orbit structure.
Area of Science:
- Orthodontics and Craniofacial Development
- Medical Imaging and Analysis
- Pediatric Skeletal Growth
Background:
- Assessing three-dimensional spatial skeletal changes in adolescent orbits.
- Utilizing cone-beam computed tomography (CBCT) for detailed imaging.
- Observing changes over a 19 to 24-month period.
Purpose of the Study:
- To quantify longitudinal skeletal changes in adolescent orbits.
- To evaluate the clinical significance of observed orbital dimension alterations.
- To establish a baseline for future craniofacial growth studies.
Main Methods:
- Sample: 50 orthodontic patients aged 11-17 years.
- Imaging: Two CBCT scans with 19-24 month interval.
- Analysis: Avizo software, 16 landmarks, 24 distances, t-test statistics.
Main Results:
- Landmark reliability was excellent (error < 1mm).
- Mean transverse, antero-posterior, and vertical changes were 0.97mm, 0.36mm, and 0.33mm.
- Greatest changes observed in transverse (4.37mm) and vertical (0.63mm) dimensions.
Conclusions:
- Adolescent orbital skeletal changes are statistically significant over 19-24 months.
- Observed changes are below 1mm on average, considered not clinically significant.
- CBCT provides reliable data for tracking subtle orbital skeletal development.
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