Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.9K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.6K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.6K
Fractures: Bone Repair01:27

Fractures: Bone Repair

6.2K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.2K
Bone Cells and Tissue01:30

Bone Cells and Tissue

9.2K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
9.2K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

12.6K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
12.6K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

10.9K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High prevalence of carbapenem-resistant Pseudomonas spp. in the pork production chain: a potential reservoir for zoonotic transmission.

Food microbiology·2026
Same author

Vertical and Horizontal Ridge Augmentation with Titanium-Reinforced Dense PTFE and Reinforced PTFE Mesh: A Prospective Comparative Case Series.

Journal of functional biomaterials·2026
Same author

Biological evaluation of gelatin-based hemostatic agents - cytocompatibility and irritation assessment.

Dental and medical problems·2026
Same author

A multi-modal approach for correlative evaluation of osteogenesis and osteoclastogenesis on laser-treated titanium, TiAl6V4, and stainless steel.

Biomaterials advances·2026
Same author

Characterization, antifungal potential, cytocompatibility, and regenerative potential of mucoadhesive gel containing antifungal-β-cyclodextrin inclusion complexes.

Journal of prosthodontics : official journal of the American College of Prosthodontists·2026
Same author

Distinct Osteogenic Profiles of Tetracyclines from Different Generations in an Ex Vivo Embryonic Chick Femur Model.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Mar 12, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

16.0K

Bone Cells Dynamics during Peri-Implantitis: a Theoretical Analysis.

Maria Helena Fernandes1, Pedro de Sousa Gomes1

  • 1Faculty of Dental Medicine, University of Porto (FMDUP), Porto Portugal.

Journal of Oral & Maxillofacial Research
|November 12, 2016
PubMed
Summary

Peri-implantitis disrupts bone remodelling by triggering an immune response that leads to alveolar bone loss. This involves immune cells influencing bone cells, causing an imbalance in bone formation and resorption.

Keywords:
alveolar bone losscellular immune responsehumoral immune responseosteoblastsosteoclastsperi-implantitis

More Related Videos

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:37

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

153
Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

778

Related Experiment Videos

Last Updated: Mar 12, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

16.0K
Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:37

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

153
Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

778

Area of Science:

  • Osteoimmunology
  • Bone Biology
  • Periodontology

Background:

  • Bone remodelling is a dynamic process regulated by intricate crosstalk between the immune and skeletal systems.
  • Peri-implantitis disrupts this balance, leading to pathological bone loss around implants.

Approach:

  • Characterizing bone cell dynamics during physiological remodelling.
  • Investigating cellular and molecular mechanisms of immune-inflammatory-induced uncoupled bone remodelling in peri-implantitis.

Key Points:

  • Immune and bone cells share receptors, cytokines, and pathways crucial for bone homeostasis.
  • Bacterial infection in peri-implantitis activates immune responses, releasing cytokines that uncouple bone resorption and formation.
  • Immune-driven osteoclast differentiation and function are key mechanisms in peri-implantitis-associated bone loss.

Conclusions:

  • Alveolar bone loss is a critical feature of peri-implantitis.
  • Further research is needed to fully elucidate the osteoimmunologic interplay in peri-implantitis for a comprehensive understanding of bone loss.