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New minor spirostanol glycosides from Helleborus thibetanus
Hui Zhang1, Yan-Fang Su1,2, Feng-Ying Yang1,3
1a Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.
Abstract:
Phytochemical reinvestigation of the dried roots and rhizomes of Helleborus thibetanus afforded four new minor spirostanol glycosides (1-4) and four known spirostanol glycosides (5-8). Their structures were determined on the basis of spectroscopic analyses, including 1D and 2D NMR experiments, together with HR-ESI-MS and IR measurements and the results of acid hydrolysis.
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