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Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations
Gianfranco Calogiuri1, Lene H Garvey, Paolo Romita
1Department of Pneumology and Allergy - Civil HospitalSacro Cuore - Gallipoli, Lecce - Italy.. Italy.
Abstract:
Glucocorticoids are the most widely used drugs for the treatment of hypersensitivity, however these drugs themselves and the excipients contained in commercial corticosteroid formulations are able to induce severe immediate-type hypersensitivity reactions. Reactions involving excipients have been confirmed to be IgE mediated by the demonstration of specific-IgE to excipients such as carboxymethylcellulose and lactose. In case of hypersensitivity reactions to corticosteroid preparations, a complete allergy work-up with skin tests and/or challenge tests should include testing excipients as well as the active ingredients.
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