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Evaluation of symptoms & spirometry in children treated for asthma
Shobi Anandi1, Milind S Tullu1, Keya Lahiri1
1Department of Pediatrics, Seth G.S. Medical College & KEM Hospital, Mumbai, India.
Insights
In children with asthma, symptom relief appeared before lung function improvements after treatment. This study tracked clinical and spirometry changes in pediatric asthma patients.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Trials
Background:
- Spirometry is crucial for asthma assessment and monitoring.
- Limited Indian research exists on pediatric spirometry due to performance difficulties.
- This study addresses the need for regular spirometry in pediatric asthma research.
Purpose of the Study:
- To evaluate clinical improvement and spirometry changes in newly diagnosed pediatric asthma patients post-treatment.
- To compare the evolution of symptom scores with spirometric measurements.
Main Methods:
- Prospective study of 32 children (6-12 years) with newly diagnosed asthma.
- Baseline and follow-up assessments (6 weeks, 3 & 6 months) included symptom scores and spirometry (FEV1, FVC, PEFR).
- Treatment was initiated, and outcomes were monitored over a six-month period.
Main Results:
- Symptom scores significantly improved by six weeks (P<0.05).
- Lung function parameters, including FEV1 and FVC, showed significant improvement at three months.
- Peak expiratory flow rate (PEFR) improved by six months, with positive correlations between symptom changes and lung function.
Conclusions:
- Symptomatic improvement in pediatric asthma is observed earlier than objective spirometric improvements after treatment initiation.
- Spirometry changes lag behind symptom relief in children undergoing asthma therapy.
Background & Objectives:
Spirometry plays an important role in the assessment and long term monitoring of patients with asthma. Difficulty in performing spirometry in children has resulted in a paucity of Indian studies using spirometry regularly for research in the paediatric population. This study was undertaken to assess the clinical improvement and changes in spirometric measurements with treatment in children with newly diagnosed asthma and to compare the changes in the symptom score and spirometric measurements.
Methods:
This prospective study included 32 children between 6 to 12 yr of age (enrolled over a period of one year with follow up of six months) who were newly diagnosed as cases of asthma on the basis of symptoms and medical history. Baseline symptom score and spirometric measurements were determined at the first visit. The children were treated and followed up at six weeks, three and six months of initiating treatment. Symptom score and spirometric measurements were repeated at every visit.
Results:
Significant improvement in symptom score was evident at six weeks of therapy ( P<0.05) while the lung function parameters FEV 1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) showed significant improvement at three months of therapy. Peak expiratory flow rate (PEFR) was found to improve at six months. There was a positive linear correlation between the changes in symptom score and FEV 1, FVC and PEFR with treatment.
Interpretation & Conclusions:
Symptomatic improvement became apparent before the improvement in spirometric parameters in children with asthma (after treatment initiation).
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