Evaluation of symptoms & spirometry in children treated for asthma

Shobi Anandi1, Milind S Tullu1, Keya Lahiri1

  • 1Department of Pediatrics, Seth G.S. Medical College & KEM Hospital, Mumbai, India.

Insights

In children with asthma, symptom relief appeared before lung function improvements after treatment. This study tracked clinical and spirometry changes in pediatric asthma patients.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Trials

Background:

  • Spirometry is crucial for asthma assessment and monitoring.
  • Limited Indian research exists on pediatric spirometry due to performance difficulties.
  • This study addresses the need for regular spirometry in pediatric asthma research.

Purpose of the Study:

  • To evaluate clinical improvement and spirometry changes in newly diagnosed pediatric asthma patients post-treatment.
  • To compare the evolution of symptom scores with spirometric measurements.

Main Methods:

  • Prospective study of 32 children (6-12 years) with newly diagnosed asthma.
  • Baseline and follow-up assessments (6 weeks, 3 & 6 months) included symptom scores and spirometry (FEV1, FVC, PEFR).
  • Treatment was initiated, and outcomes were monitored over a six-month period.

Main Results:

  • Symptom scores significantly improved by six weeks (P<0.05).
  • Lung function parameters, including FEV1 and FVC, showed significant improvement at three months.
  • Peak expiratory flow rate (PEFR) improved by six months, with positive correlations between symptom changes and lung function.

Conclusions:

  • Symptomatic improvement in pediatric asthma is observed earlier than objective spirometric improvements after treatment initiation.
  • Spirometry changes lag behind symptom relief in children undergoing asthma therapy.
Abstract

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