Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Cancer Vaccines01:30

Cancer Vaccines

1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IMPALEMENT HEAD INJURY WITH A SPEAR.

Journal of the West African College of Surgeons·2017
Same author

Immunosuppression in liver tumors: opening the portal to effective immunotherapy.

Cancer gene therapy·2016
Same author

The impact of age on nodal metastases and survival in gastric cancer.

The Journal of surgical research·2016
Same author

Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases.

Cancer gene therapy·2016
Same author

Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery.

Cancer gene therapy·2016
Same author

Neutrophil:lymphocyte ratios and serum cytokine changes after hepatic artery chimeric antigen receptor-modified T-cell infusions for liver metastases.

Cancer gene therapy·2014
Same journal

VPS37A loss creates CASP8-dependent vulnerability via the MAP3K7-NF-κB-CFLAR axis.

Cancer gene therapy·2026
Same journal

Correction: Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum.

Cancer gene therapy·2026
Same journal

Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum.

Cancer gene therapy·2026
Same journal

NCBP1 promotes the malignant progression of Wilms' tumor through stabilization of KPNA2 mRNA.

Cancer gene therapy·2026
Same journal

Reprogramming the tumor microenvironment via TFF3 targeting: a potential novel avenue to boost CAR-T cell therapy in solid tumors.

Cancer gene therapy·2026
Same journal

Hepatitis B virus-induced hepatocellular carcinoma: HBx-associated epigenetic mechanisms and therapeutic opportunities.

Cancer gene therapy·2026
See all related articles

Related Experiment Video

Updated: Mar 12, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.1K

Combinatorial immunotherapy for melanoma.

D D George1, V A Armenio2,3, S C Katz4,5

  • 1Division of Dermatology, Roger Williams Medical Center, Department of Medicine RWMC, Providence, RI, USA.

Cancer Gene Therapy
|November 12, 2016
PubMed
Summary
This summary is machine-generated.

This review covers the history and recent advances in melanoma immunotherapy, highlighting novel treatment combinations for advanced melanoma patients.

More Related Videos

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

24.1K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.3K

Related Experiment Videos

Last Updated: Mar 12, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.1K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

24.1K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.3K

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Melanoma remains a significant challenge in cancer treatment.
  • Immunotherapy has emerged as a key strategy for melanoma.
  • The evolution of treatment necessitates a review of current and future options.

Purpose of the Study:

  • To review the historical development of melanoma immunotherapy.
  • To highlight recent breakthroughs and advancements in the field.
  • To explore novel combination therapies for advanced melanoma.

Main Methods:

  • Literature review of melanoma treatment evolution.
  • Analysis of historical and current immunotherapy approaches.
  • Discussion of emerging combination strategies.

Main Results:

  • Immunotherapy has transformed melanoma treatment paradigms.
  • Recent advances include checkpoint inhibitors and targeted therapies.
  • Combination therapies show promise for improved patient outcomes.

Conclusions:

  • Continued research into melanoma immunotherapy is crucial.
  • Novel combinations offer potential for enhanced therapeutic efficacy.
  • Personalized treatment strategies are key for advanced melanoma management.