Related Experiment Video
Updated: Mar 12, 2026

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
Published on: October 27, 2023
Imaging techniques: new avenues in cancer gene and cell therapy
Z Saadatpour1, A Rezaei2, H Ebrahimnejad3
1Bozorgmehr Imaging Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:
Cancer is one of the world's most concerning health problems and poses many challenges in the range of approaches associated with the treatment of cancer. Current understanding of this disease brings to the fore a number of novel therapies that can be useful in the treatment of cancer. Among them, gene and cell therapies have emerged as novel and effective approaches. One of the most important challenges for cancer gene and cell therapies is correct monitoring of the modified genes and cells. In fact, visual tracking of therapeutic cells, immune cells, stem cells and genetic vectors that contain therapeutic genes and the various drugs is important in cancer therapy. Similarly, molecular imaging, such as nanosystems, fluorescence, bioluminescence, positron emission tomography, single photon-emission computed tomography and magnetic resonance imaging, have also been found to be powerful tools in monitoring cancer patients who have received therapeutic cell and gene therapies or drug therapies. In this review, we focus on these therapies and their molecular imaging techniques in treating and monitoring the progress of the therapies on various types of cancer.
Insights
Monitoring cancer gene and cell therapies is crucial. Molecular imaging techniques like nanosystems and MRI offer powerful tools for tracking therapeutic progress in cancer patients.
Area of Science:
- Oncology
- Biomedical Engineering
- Molecular Imaging
Background:
- Cancer presents significant global health challenges, necessitating advanced treatment strategies.
- Gene and cell therapies offer promising, novel approaches for cancer treatment.
- Effective monitoring of these therapies is essential for successful patient outcomes.
Purpose of the Study:
- To review current gene and cell therapies for cancer.
- To highlight the importance of monitoring therapeutic progress.
- To explore molecular imaging techniques for tracking these advanced treatments.
Main Methods:
- Review of scientific literature on cancer gene and cell therapies.
- Analysis of molecular imaging modalities used in cancer monitoring.
- Discussion of techniques including nanosystems, fluorescence, bioluminescence, PET, SPECT, and MRI.
Main Results:
- Gene and cell therapies are emerging as effective cancer treatments.
- Molecular imaging provides critical insights into therapeutic cell and gene tracking.
- Various imaging techniques demonstrate utility in monitoring treatment efficacy.
Conclusions:
- Accurate monitoring is vital for the success of cancer gene and cell therapies.
- Molecular imaging modalities are indispensable tools for visualizing and tracking therapeutic interventions.
- This review consolidates knowledge on advanced therapies and their monitoring in oncology.
More Related Videos
10:04Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
Published on: March 13, 2018
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Tumor Immunotherapy
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer
Gene Therapy