Related Experiment Video
Updated: Mar 12, 2026
07:55
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
1.9K
Intraperitoneal immunotherapy: historical perspectives and modern therapy
W F Morano1, A Aggarwal1, P Love1
1Department of Surgery, Drexel University College of Medicine, Philadelphia, PA, USA.
Cancer Gene Therapy
|November 12, 2016
Summary
Intraperitoneal immunotherapy offers a new approach for peritoneal metastases (PM). Emerging treatments show promise in controlling cancer spread and building lasting immunity, potentially improving outcomes beyond surgery and chemotherapy.
Area of Science:
- Oncology
- Immunology
Background:
- Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are standard for peritoneal metastases (PM), but recurrence rates and survival remain suboptimal.
- Anticancer immunotherapies are being explored for regional disease control in the peritoneal cavity.
Observation:
- Various immunotherapeutic strategies, including vaccines, adoptive cell transfer, immune checkpoint inhibitors, and CAR-T cells, are under investigation for intraperitoneal use.
- Catumaxomab, a trifunctional antibody, is approved in Europe for malignant ascites in specific cancers.
Findings:
- Early studies indicate that intraperitoneal immunotherapy can control peritoneal spread.
- These novel approaches aim to induce lasting anticancer immunity.
Implications:
- Intraperitoneal immunotherapy presents a promising novel strategy for managing peritoneal metastases.
- Further research may lead to improved long-term survival and reduced recurrence for patients with PM.
Related Concept Videos
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
01:30Cancer Vaccines
1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
01:29Inflammatory Bowel Disease IV: Pharmacological Management
884
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
884