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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Gene Therapy: A Paradigm Shift in Dentistry.

Nida Siddique1, Hira Raza2, Sehrish Ahmed3

  • 1Department of Oral Biology, Bahria University Medical and Dental College, Karachi 75260, Pakistan. nidasiddique@hotmail.com.

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Gene therapy offers a promising, minimally invasive approach to dentistry, transforming treatments with precise, preventive genetic engineering. This review explores its applications and benefits for oral health.

Keywords:
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Area of Science:

  • Oral medicine and dentistry
  • Biotechnology and genetic engineering

Background:

  • Gene therapy presents a paradigm shift in dental treatment, moving towards precision and prevention.
  • The oral cavity's accessibility makes it an ideal site for gene therapy applications.
  • Conventional treatments often involve drugs and surgery, carrying systemic risks and invasiveness.

Approach:

  • This article reviews current gene therapy applications within the field of dentistry.
  • It examines the therapeutic advantages, including disease treatment and improved patient outcomes.
  • Focus is placed on the minimally invasive nature of gene therapy compared to traditional methods.

Key Points:

  • Gene therapy enables precise and preventive dental treatments, reducing reliance on drugs and surgery.
  • The oral cavity offers a unique and accessible platform for in vivo gene therapy.
  • Advantages include avoiding invasive procedures, deep wounds, and systemic drug side effects.

Conclusions:

  • Gene therapy is poised to revolutionize dentistry by offering advanced, less invasive treatment options.
  • Its application in dentistry promises enhanced therapeutic benefits with maximal outcomes.
  • Further research and clinical integration of gene therapy will advance oral healthcare significantly.