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Related Experiment Video

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Published on: June 7, 2019

K-ras oncogene mutation in pterygium.

B T Ozturk¹, M S Yıldırım², A Zamani²

¹Faculty of Medicine, Department of Ophthalmology, Selçuk University, Konya, Turkey.

Eye (London, England)

|November 12, 2016

Summary

Pterygium tissue shows a higher frequency of K-ras oncogene mutations, particularly at codon 61, suggesting a potential tumoral origin. This finding supports research into targeted therapies beyond surgical excision for pterygium.

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Area of Science:

Ophthalmology
Oncology
Molecular Biology

Background:

Pterygium is traditionally considered a benign eye condition linked to UV exposure.
The role of oncogene mutations in pterygium development is not fully understood.

Purpose of the Study:

To investigate the frequency of K-ras oncogene mutations in pterygium tissues.
To evaluate the potential tumoral origin of pterygium based on genetic mutations.

Main Methods:

Prospective analysis of pterygium and normal conjunctiva tissues from 25 patients.
DNA extraction followed by Polymerase Chain Reaction (PCR) amplification of K-ras gene codons 12, 13, and 61.
Pyrosequencing to detect mutations at these specific codons.

Main Results:

No K-ras mutations were found in normal conjunctival tissues.
Pterygium tissues exhibited significant K-ras mutations at codon 61 (7 cases) and codon 12 (1 case) (P<0.05).
Specific mutations at codon 61 included glutamine to arginine (4 cases) and glutamine to leucine (3 cases).

Conclusions:

The elevated K-ras mutation rate in pterygium supports its potential tumoral origin.
These findings suggest a basis for developing targeted therapies for pterygium.
Further research into targeted treatments could offer improved outcomes compared to current surgical methods.