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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Iris Fixation via External Pentagram Suturing
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Peripapillary schisis in open-angle glaucoma.

N Dhingra1, R Manoharan1, S Gill1

  • 1Pinderfields Hospital, Mid Yorkshire NHS Trust, Wakefield, UK.

Eye (London, England)
|November 12, 2016
PubMed
Summary
This summary is machine-generated.

Peripapillary schisis in open-angle glaucoma can resolve spontaneously. However, its resolution may affect retinal nerve fibre layer thickness measurements, requiring careful interpretation of optical coherence tomography scans.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optical Coherence Tomography

Background:

  • Peripapillary schisis is a condition that can occur in patients with open-angle glaucoma.
  • Understanding its clinical features and outcomes is crucial for patient management.

Purpose of the Study:

  • To describe the clinical characteristics, imaging findings, and prognosis of peripapillary schisis in eyes with open-angle glaucoma.
  • To investigate the relationship between peripapillary schisis and optical coherence tomography (OCT) findings.

Main Methods:

  • Retrospective review of 10 eyes from 9 patients diagnosed with open-angle glaucoma and peripapillary schisis.
  • Analysis of serial OCT and infrared imaging, visual acuity, visual fields, and intraocular pressure.
  • Monitoring schisis resolution and changes in retinal nerve fibre layer (RNFL) thickness.

Main Results:

  • Peripapillary schisis was observed in all 10 eyes, with macular schisis in one.
  • No cases of acquired optic nerve pits or pathological myopia were noted.
  • Schisis resolved in 4 eyes over a mean follow-up of 21.2 months; visual field worsening occurred in 4 eyes.
  • Schisis resolution correlated with a significant reduction in RNFL thickness.

Conclusions:

  • Peripapillary schisis in open-angle glaucoma can resolve spontaneously and infrequently involves the macula.
  • Resolution of schisis leads to decreased RNFL thickness, necessitating caution when interpreting serial OCT scans.
  • This finding impacts the assessment of glaucoma progression using RNFL measurements.