Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.7K
Development of Immunocompetence01:22

Development of Immunocompetence

1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Vaccinations01:51

Vaccinations

53.1K
Overview
53.1K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.4K
Humoral Immune Responses01:36

Humoral Immune Responses

85.3K
Overview
85.3K
Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consanguinity in the Lebanese population: knowledge, attitudes and practices.

Journal of community genetics·2026
Same author

Assessment of TREC-Based NBS SCID Reporting Practices for Harmonization of Results and Interpretation: A Global Survey.

The journal of allergy and clinical immunology. In practice·2026
Same author

PAFLAR guidelines for oligoarticular juvenile idiopathic arthritis.

Clinical rheumatology·2026
Same author

Study of Interferon-Induced Transmembrane Protein 3 Gene Polymorphism and Serum Interferon-λ3 Level in COVID-19.

International journal of immunogenetics·2025
Same author

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry.

Frontiers in genetics·2025
Same author

The pagers explosions in Beirut: Injury profiles, surgical care, and medical interventions-A descriptive study from a tertiary care medical center.

The journal of trauma and acute care surgery·2025

Related Experiment Video

Updated: Mar 12, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

24.1K

Vaccination in Primary Immunodeficiency Disorders.

Ali Sobh1, Francisco A Bonilla2

  • 1Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

The Journal of Allergy and Clinical Immunology. in Practice
|November 13, 2016
PubMed
Summary

Vaccination is crucial for immunocompromised patients to prevent infections. This review provides evidence-based recommendations for using live and inactivated vaccines based on the patient

Keywords:
Immune dysregulationInactivated vaccinesLive vaccinesPrimary immunodeficiencyVaccination

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K
Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
09:03

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

9.3K

Related Experiment Videos

Last Updated: Mar 12, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

24.1K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K
Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
09:03

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

9.3K

Area of Science:

  • Immunology
  • Vaccinology
  • Clinical Medicine

Background:

  • Immunocompromised patients face higher risks of vaccine-preventable infections.
  • Vaccine administration in this population requires careful consideration of risks and benefits.
  • Vaccines are broadly categorized into live (attenuated) and inactivated (nonviable) types.

Purpose of the Study:

  • To provide clear, evidence-based recommendations for vaccinating immunocompromised patients.
  • To differentiate vaccine safety and efficacy based on vaccine type (live vs. inactivated) and degree of immune compromise.
  • To guide clinical decision-making for routine and specialized vaccines in diverse immunodeficiency disorders.

Main Methods:

  • Systematic review of available evidence on vaccine use in immunocompromised individuals.
  • Analysis of vaccine classifications (live, inactivated, subunit) and their implications.
  • Categorization of immunodeficiency disorders and assessment of immune compromise levels.

Main Results:

  • Inactivated vaccines are generally safe and recommended for immunocompromised patients, with exceptions in severe antibody deficiencies.
  • Live vaccines pose a risk of disease in severely immunocompromised individuals, requiring individualized risk-benefit assessment.
  • Recommendations are tailored based on the specific immunodeficiency, vaccine type, and potential for infection versus adverse effects.

Conclusions:

  • Vaccination strategies for immunocompromised patients must be individualized.
  • A careful balance between infection risk and vaccine-related adverse events is essential.
  • This review offers a framework for optimizing vaccine use in this vulnerable population.