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Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection

Xiaotong Cui1, Jingmin Zhou1, Xuejuan Jin1

  • 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

International Journal of Cardiology
|November 13, 2016
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) affects nearly a third of elderly individuals, particularly women. Heart failure with preserved ejection fraction (HFpEF) also increases with age, with distinct risk factors at different stages.

Area of Science:

  • Cardiology
  • Geriatrics
  • Public Health

Background:

  • Left ventricular diastolic dysfunction (LVDD) is strongly linked to heart failure with preserved ejection fraction (HFpEF).
  • The prevalence and contributing factors of LVDD and HFpEF in the elderly population are not well understood.

Purpose of the Study:

  • To determine the prevalence of LVDD and HFpEF in a community-dwelling elderly population.
  • To identify the demographic, clinical, and biochemical correlates of LVDD and HFpEF in this cohort.

Main Methods:

  • The Shanghai Heart Health Study enrolled 1274 residents aged 65 years and older.
  • Demographic, laboratory, and echocardiographic data were collected.
  • Univariate and multivariate logistic regression analyses were used to identify correlates of LVDD and HFpEF.

Main Results:

  • LVDD was prevalent in 31.9% of residents, more common in women. HFpEF prevalence was 2.8% and increased with age.
  • Independent correlates of asymptomatic LVDD included female sex, heart rate, atrial fibrillation, hypertension, NT-proBNP, and hs-TnT.
  • Age, heart rate, and hs-TnT were independently associated with HFpEF.

Conclusions:

  • LVDD and HFpEF are common conditions in the elderly Chinese population.
  • Different factors are associated with LVDD and HFpEF, suggesting distinct pathophysiological pathways.
  • Further research is needed to elucidate predictors of LVDD and HFpEF in the elderly.
Abstract

Keywords:
Diastolic dysfunctionElderlyEpidemiologyHeart failurePreserved ejection fraction

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