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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Ocular pyoderma gangrenosum: A systematic review.

Angela S Gupta¹, Alex G Ortega-Loayza²

¹School of Medicine, Virginia Commonwealth University, Richmond, Virginia.

Journal of the American Academy of Dermatology

|November 13, 2016

Summary

Ocular pyoderma gangrenosum (PG) is rare but serious. Early, aggressive multimodal treatment, especially for eye/orbit involvement, is crucial to prevent relapse of this ulcerative skin disorder.

Keywords:

extracutaneous eye inflammation neutrophilic dermatoses ocular periorbital pyoderma gangrenosum

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Published on: May 25, 2022

Area of Science:

Ophthalmology
Dermatology
Systematic Review

Background:

Pyoderma gangrenosum (PG) is a rare ulcerative skin condition.
Ophthalmic involvement is uncommon but can lead to severe outcomes.

Purpose of the Study:

To characterize ocular pyoderma gangrenosum (PG) for improved diagnosis and treatment.
This is the first systematic review of this ocular variant.

Main Methods:

Systematic review of PubMed and Web of Science databases.
Qualitative assessment and analysis of extracted data from identified studies.

Main Results:

34 cases of ocular/periorbital PG were identified and categorized into 4 subtypes.
Common signs include ulceration, peripheral ulcerative keratitis, and vision loss.
Combined corticosteroid and surgical therapy is standard; aggressive treatment is vital for eye/orbit cases due to higher relapse rates.

Conclusions:

Ocular PG should be considered in differential diagnoses for ocular/periocular ulcerations.
An aggressive, early, multimodal treatment strategy is recommended to prevent relapse, particularly for eye/orbit involvement.