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Treatment dilemmas in Guillain-Barré syndrome

Christine Verboon1, Pieter A van Doorn1, Bart C Jacobs1,2

  • 1Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.

Journal of Neurology, Neurosurgery, and Psychiatry
|November 13, 2016
PubMed

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical course and outcome. Intravenous immunoglobulin (IVIg) and plasma exchange are proven effective treatments, but the efficacy has been demonstrated mainly on motor improvement in adults with a typical and severe form of GBS. In clinical practice, treatment dilemmas may occur in patients with a relatively mild presentation, variant forms of GBS, or when the onset of weakness was more than 2 weeks ago. Other therapeutic dilemmas may arise in patients who do not improve or even progress after initial treatment. We provide an overview of the current literature about therapeutic options in these situations, and additionally give our personal view that may serve as a basis for therapeutic decision-making.

Keywords:
GUILLAIN-BARRE SYNDROME

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