Related Experiment Video
Updated: Mar 12, 2026
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
The role of microRNAs in myopia
Bo Jiang1, Yanan Huo2, Yangshun Gu1
1Department of Ophthalmology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qinchun Road, Hangzhou, Zhejiang, 310003, China.
Purpose:
In recent years, research on microRNAs (miRNAs) has become popular because of the critical role these macromolecules play in post-transcriptional gene regulation. Recent efforts have been made to identify miRNAs and their possible roles in myopia. The aim of this review was to summarize the expression and function of miRNAs during the development of myopia.
Methods:
In this article, we reviewed the current research on the mechanisms that regulate miRNA expression, the potential for miRNAs as a diagnostic biomarker for myopia, and the mechanisms by which miRNAs promote the development of myopia. We also discussed the miRNA expression profiles in human fetal sclera.
Results:
We summarized the miRNA expression profiles in myopia, including miR-328, miR-184, miR-29a, and miR-let-7i, and also the miRNA expression profiles in fetal sclera, including miR-214, miR-let-7, miR-103, miR-107, miR-29b, miR-328, and miR-98.
Conclusions:
Such knowledge could lead to more precise diagnosis, prognosis, and response predictions for future treatments for myopia, and the pace of discovery is expected to accelerate dramatically in the near future.
Insights
MicroRNAs (miRNAs) are key in gene regulation and myopia development. This review summarizes miRNA roles, expression, and potential as myopia biomarkers.
Area of Science:
- Ophthalmology
- Molecular Biology
- Genetics
Background:
- MicroRNAs (miRNAs) are crucial regulators of post-transcriptional gene expression.
- Emerging research highlights the significant role of miRNAs in the pathogenesis of myopia.
- Understanding miRNA involvement is vital for advancing myopia research.
Purpose of the Study:
- To review the current literature on microRNA expression and function in myopia development.
- To explore the potential of miRNAs as diagnostic biomarkers for myopia.
- To elucidate the mechanisms by which miRNAs contribute to myopia progression.
Main Methods:
- Comprehensive literature review of studies on miRNA regulation and function in myopia.
- Analysis of miRNA expression profiles in human myopia and fetal sclera.
- Examination of the role of specific miRNAs (e.g., miR-328, miR-184) in myopia.
Main Results:
- Identified specific miRNA expression profiles associated with myopia, including miR-328, miR-184, miR-29a, and miR-let-7i.
- Detailed miRNA expression patterns in human fetal sclera, noting miR-214, miR-let-7, miR-103, miR-107, miR-29b, miR-328, and miR-98.
- Highlighted the regulatory functions of miRNAs in the context of myopia.
Conclusions:
- Knowledge of miRNA roles in myopia can improve diagnosis and prognosis.
- miRNAs hold promise for predicting treatment responses in myopia patients.
- Accelerated discovery in miRNA research is anticipated for myopia management.
More Related Videos
06:58Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
Published on: May 18, 2022
13:47Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
Related Concept Videos
01:22MicroRNAs
01:22MicroRNAs